Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9459967 | 0.84 | CYP19A1 (0.41) | CYP19A1ALDH1A1SMN1; SMN2FDPS | |
| SCHEMBL3700407 | 0.82 | ALDH1A1 (0.37) | CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3695170 | 0.79 | CYP19A1 (0.39) | CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27922362 | 0.78 | CYP19A1 (0.38) | CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3707615 | 0.78 | ALDH1A1 (0.39) | CYP19A1ALDH1A1SMN1; SMN2FDPS | |
| SCHEMBL22059382 | 0.77 | CYP19A1 (0.37) | CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11210714 | 0.76 | CYP19A1 (0.33) | CYP19A1FDPS | |
| SCHEMBL4021142 | 0.73 | CYP19A1 (0.36) | CYP19A1ALDH1A1SMN1; SMN2FDPS | |
| SCHEMBL21554045 | 0.73 | CYP19A1 (0.30) | CYP19A1 | |
| SCHEMBL19983268 | 0.73 | HRH4 (0.40) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | disclosed |