Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353493 | 0.87 | FFAR1 (0.50) | FFAR1LIPGFFAR4CHRM2S1PR1 | |
| SCHEMBL28073277 | 0.86 | FFAR1 (0.50) | FFAR1LIPGFFAR4CHRM2S1PR1 | |
| SCHEMBL9356039 | 0.82 | LIPG (0.50) | FFAR1LIPGFFAR4CYP3A4CYP2C9 | |
| SCHEMBL9332666 | 0.78 | FFAR1 (0.49) | FFAR1LIPGFFAR4CYP3A4CYP2C9 | |
| SCHEMBL4967360 | 0.76 | HSD17B10 (0.46) | FFAR1LIPGFFAR4CHRM2CYP3A4 | |
| SCHEMBL5314930 | 0.76 | LIPG (0.42) | FFAR1LIPGCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL27441496 | 0.75 | FFAR1 (0.43) | FFAR1LIPGFFAR4CHRM2S1PR1 | |
| SCHEMBL10591869 | 0.75 | FFAR1 (0.51) | FFAR1FFAR4CHRM2S1PR1FPR1 | |
| Hexane SCHEMBL27681135 | 0.75 | FFAR1 (0.52) | FFAR1FFAR4CHRM2S1PR1FPR1 | |
| SCHEMBL8753934 | 0.74 | FFAR1 (0.38) | FFAR1LIPGFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756081-A1 | 1,1'-(1,2-ETHYNEDIYL)BIS-BENZENE DERIVATIVES AS PTP 1-B INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005097773-A1 | 1,1’-(1,2-ETHYNEDIYL)BIS-BENZENE DERIVATIVES AS PTP 1-B INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-10-20 | — | — | WO | disclosed |