Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.35 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222059 | 0.84 | KDM4E (0.50) | ALOX5HRH4KDM4EMAPK1ATM | |
| Iodide SCHEMBL2220742 | 0.82 | KDM4E (0.48) | ALOX5HRH4KDM4EMAPK1ATM | |
| Hydrochloric Acid SCHEMBL2222074 | 0.82 | KDM4E (0.48) | ALOX5HRH4KDM4EMAPK1ATM | |
| Maleic Acid SCHEMBL7778373 | 0.80 | HCAR2 (0.50) | ALOX5KDM4EPKMMAPTHRH2 | |
| Phthalic Anhydride SCHEMBL27856846 | 0.72 | TDP1 (0.64) | KDM4EPKMMAPTALDH1A1MEN1 | |
| SCHEMBL2749071 | 0.72 | TOP1 (0.42) | ALOX5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5693983 | 0.68 | MAPK1 (0.61) | ALOX5KDM4EPKMMAPTMEN1 | |
| SCHEMBL19537981 | 0.68 | MAPK1 (0.61) | ALOX5KDM4EPKMMAPTMEN1 | |
| Fumaric Acid SCHEMBL4003747 | 0.68 | KDM4E (0.42) | ALOX5KDM4EPKMMAPTALDH1A1 | |
| Maleic Acid SCHEMBL4003742 | 0.68 | KDM4E (0.42) | ALOX5KDM4EPKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013041604-A1 | CRYSTAL FORM OF ASENAPINE MALEATE | SANDOZ AG (CH) | 2013-03-28 | — | — | WO | disclosed |
| EP-1802301-A1 | TREATMENT OF BIPOLAR DISORDERS AND ASSOCIATED SYMPTOMS | PFIZER INC. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040314-A1 | TREATMENT OF BIPOLAR DISORDERS AND ASSOCIATED SYMPTOMS | PFIZER INC. (US) | 2006-04-20 | — | — | WO | disclosed |