Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5501776 | 1.00 | DRD2 (0.32) | DRD2PTGS2DRD3MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL5501745 | 0.96 | DRD2 (0.33) | DRD2PTGS2DRD3MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL8707095 | 0.94 | HDAC1 (0.31) | HDAC1 | |
| Trifluoroacetic Acid SCHEMBL8707075 | 0.94 | HDAC1 (0.31) | HDAC1 | |
| Trifluoroacetic Acid SCHEMBL8707018 | 0.93 | MAPT (0.33) | DRD2PTGS2DRD3MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL8705773 | 0.93 | HDAC1 (0.33) | MAPTTDP1POLBPKMHTT | |
| Trifluoroacetic Acid SCHEMBL8703933 | 0.93 | HSP90AA1 (0.35) | MAPTMEN1KMT2ATDP1POLB | |
| Trifluoroacetic Acid SCHEMBL8705695 | 0.92 | HDAC1 (0.31) | MAPTTDP1POLBPKMHTT | |
| Trifluoroacetic Acid SCHEMBL5507641 | 0.92 | HDAC1 (0.34) | MAPTTDP1POLBPKMHTT | |
| Trifluoroacetic Acid SCHEMBL5507637 | 0.92 | HDAC1 (0.34) | MAPTTDP1POLBPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| EP-0911030-B1 | Antimicrobial composition comprising a vinyyl pyrrolidinon derivative and a carbapenem antibiotic or a beta-lactamase inhibitor | BASILEA PHARMACEUTICA AG (CH) | 2005-04-13 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| US-6150350-A | CARBAPENEM ANTIBIOTIC AND BETA-LACTAMASE INHIBITOR, USEFUL FOR THE TREATMENT AND PROPHYLAXIS OF INFECTIOUS DISEASES | HOFFMAN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0911030-A2 | Antimicrobial composition comprising a vinyyl pyrrolidinon derivative and a carbapenem antibiotic or a beta-lactamase inhibitor | F.HOFFMANN-LA ROCHE AG (CH) | 1999-04-28 | — | — | EP | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |
| EP-0838465-A1 | Pyridinium-substituted (lactamylvinyl)cephalosporin derivatives, their preparation and their use as antibiotics | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-29 | — | — | EP | disclosed |