Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.68 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.68 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.68 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.68 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.68 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.68 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CASP7 | P55210 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500530 | 0.88 | GPBAR1 (0.66) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL5504189 | 0.88 | GPBAR1 (0.62) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL30094040 | 0.87 | GPBAR1 (0.69) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL30094045 | 0.87 | GPBAR1 (0.63) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL31456225 | 0.85 | GPBAR1 (0.66) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL28036815 | 0.85 | GPBAR1 (0.66) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL19713107 | 0.84 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL22769482 | 0.84 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL13592769 | 0.84 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL18733391 | 0.84 | GPBAR1 (0.82) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392713-B1 | LIVER X RECEPTOR AGONISTS | UNIV CHICAGO (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20070032464-A1 | Methods of treating cancers | UNIVERSITY OF CHICAGO, THE | 2007-02-08 | — | — | US | disclosed |
| US-7012069-B2 | Liver X receptor agonists | ARCH DEVELOPMENT CORPORATION (US) | 2006-03-14 | — | — | US | disclosed |
| EP-1392713-A4 | LIVER X RECEPTOR AGONISTS | UNIV CHICAGO (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1392713-A2 | LIVER X RECEPTOR AGONISTS | The University of Chicago (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20020193357-A1 | Liver X receptor agonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-12-19 | — | — | US | disclosed |
| WO-2002090375-A2 | LIVER X RECEPTOR AGONISTS | THE UNIVERSITY OF CHICAGO (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193357-A1 | Liver X receptor agonists | NR1H3, NR1H2, NR1H4 | GPBAR1 8/4885EPHA2 1102/4885HSD17B10 343/4885 |
| US-20070032464-A1 | Methods of treating cancers | VHL, CD44, CA4 | GPBAR1 2305/4885EPHA2 1347/4885HSD17B10 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.