Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505978 | 0.81 | HRH1 (0.41) | SLC18A3DRD2ALDH1A1 | |
| SCHEMBL4972910 | 0.79 | — | — | |
| SCHEMBL6991321 | 0.65 | DRD2 (0.53) | RECQLSLC18A3DRD2 | |
| SCHEMBL6926444 | 0.64 | ABCB1 (0.49) | KDM4ESLC18A3DRD2PARP1ALDH1A1 | |
| SCHEMBL6926358 | 0.62 | DRD2 (0.40) | KDM4EHRH3KMT2ADRD2PARP1 | |
| SCHEMBL8043820 | 0.62 | DRD2 (0.54) | KDM4EHRH3SLC18A3KMT2ADRD2 | |
| SCHEMBL26157325 | 0.61 | DRD2 (0.42) | HRH3SLC18A3DRD2 | |
| SCHEMBL13843096 | 0.61 | DRD2 (0.50) | HRH3DRD2 | |
| SCHEMBL3769797 | 0.60 | DRD2 (0.46) | KDM4EHRH3KMT2ADRD2 | |
| SCHEMBL6924461 | 0.60 | KDM4E (0.51) | KDM4EL3MBTL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |