Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.81 |
| ▸ | EGFR | P00533 | 6/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 7/20 | 0.49 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.49 |
| ▸ | NLK | Q9UBE8 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.49 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510530 | 0.92 | SRC (0.73) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL19617953 | 0.85 | SRC (0.81) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL19209424 | 0.85 | SRC (0.81) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL7015603 | 0.85 | SRC (0.73) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL6188668 | 0.81 | SRC (0.82) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL6185479 | 0.81 | SRC (0.73) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL7012160 | 0.81 | SRC (0.73) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL19209392 | 0.79 | SRC (0.77) | SRCEGFRRIPK2NOD1GAK | |
| SCHEMBL22766354 | 0.79 | SRC (0.48) | SRCEGFRRIPK2GAKCOQ8A | |
| SCHEMBL7014373 | 0.77 | SRC (0.67) | SRCEGFRRIPK2NOD1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802581-A1 | 4 [(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-ALKOXY-7-ETHYNYL-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF ISCHEMIC INJURY | Wyeth a Corporation of the State of Delaware (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006047262-A1 | 4 [(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-ALKOXY-7-ETHYNYL-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF ISCHEMIC INJURY | WYETH (US) | 2006-05-04 | — | — | WO | disclosed |