Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.67 |
| ▸ | GAK | O14976 | 5/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012160 | 0.81 | SRC (0.73) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL7015603 | 0.81 | SRC (0.73) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL19209424 | 0.79 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL14923429 | 0.79 | HTT (0.57) | ABCG2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL5254846 | 0.79 | SRC (0.70) | SRC | |
| SCHEMBL7015262 | 0.77 | SRC (0.66) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL5502139 | 0.77 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL19617953 | 0.77 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL7008456 | 0.76 | SRC (0.67) | SRCGAKMAPTHPGDSMN1; SMN2 | |
| SCHEMBL5050786 | 0.76 | KDR (0.58) | SRCGAKRIPK2EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |