Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.73 |
| ▸ | GAK | O14976 | 8/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.51 |
| ▸ | NLK | Q9UBE8 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015603 | 0.85 | SRC (0.73) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL7014373 | 0.81 | SRC (0.67) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL7015262 | 0.81 | SRC (0.66) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL5502139 | 0.81 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL19617953 | 0.81 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL19209424 | 0.81 | SRC (0.81) | SRCGAKRIPK2EGFRNOD1 | |
| SCHEMBL7008456 | 0.80 | SRC (0.67) | SRCGAKALDH1A1MAPT | |
| SCHEMBL26086336 | 0.79 | GAK (0.65) | SRCGAKRIPK2EGFRALK | |
| SCHEMBL7016099 | 0.78 | SRC (0.61) | SRCGAKALKPOLBTHRB | |
| SCHEMBL26087214 | 0.78 | GAK (0.63) | SRCGAKRIPK2EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |