Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.54 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | CDK9 | P50750 | 5/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499160 | 0.88 | SYK (0.53) | CCNT1CDK2CDK9CCNE1CCNA2 | |
| SCHEMBL5502604 | 0.83 | SYK (0.54) | CDK2NTRK1PLK4GAKJAK2 | |
| SCHEMBL5501739 | 0.79 | ALDH1A1 (0.53) | JAK3 | |
| SCHEMBL5499607 | 0.78 | CTSC (0.62) | — | |
| SCHEMBL15805160 | 0.77 | PLK4 (0.46) | HDAC3HDAC1HDAC2HDAC6CCNT1 | |
| SCHEMBL14342346 | 0.76 | PDPK1 (0.52) | — | |
| SCHEMBL5526330 | 0.75 | TSHR (0.43) | HDAC3HDAC1HDAC2HDAC6JAK3 | |
| SCHEMBL29371274 | 0.74 | CDK2 (0.62) | HDAC3HDAC1HDAC2HDAC6CCNT1 | |
| SCHEMBL12614697 | 0.74 | HDAC3 (0.64) | HDAC3HDAC1HDAC2HDAC6CCNT1 | |
| SCHEMBL19909277 | 0.74 | HDAC3 (0.54) | HDAC3HDAC1HDAC2HDAC6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | claimed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | TTK, CHEK2, ABL1 | HDAC3 1269/4885HDAC1 726/4885HDAC2 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.