Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245157 | 0.90 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3241519 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3245109 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL13293346 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL13293317 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3245238 | 0.80 | MAPT (0.55) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL17507532 | 0.78 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3247653 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3234337 | 0.77 | RAB9A (0.72) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3244264 | 0.77 | RAB9A (0.67) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751097-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | Proteotech, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113489-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH, INC. (US) | 2005-12-01 | — | — | WO | disclosed |