Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 16/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524948 | 0.84 | DHFR (0.48) | DHFRALOX5APFEN1 | |
| SCHEMBL4516307 | 0.81 | DHFR (0.73) | DHFRMAP4K4DCPS | |
| SCHEMBL8512311 | 0.81 | DHFR (1.00) | DHFRMAP4K4DCPSHRH4 | |
| SCHEMBL4527349 | 0.80 | PTPN1 (0.47) | DHFRALOX5APFEN1 | |
| SCHEMBL4518205 | 0.78 | DHFR (0.68) | DHFRMAP4K4ALOX5APFEN1DCPS | |
| SCHEMBL8509933 | 0.78 | DHFR (1.00) | DHFRMAP4K4DCPS | |
| SCHEMBL4528737 | 0.78 | DHFR (0.68) | DHFRMAP4K4ALOX5APFEN1DCPS | |
| SCHEMBL4356736 | 0.76 | ALOX5AP (0.43) | DHFRALOX5APFEN1 | |
| SCHEMBL9605513 | 0.76 | DHFR (1.00) | DHFRMAP4K4DCPSHRH4 | |
| SCHEMBL4532433 | 0.75 | DHFR (0.68) | DHFRMAP4K4ALOX5APFEN1DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | disclosed |