Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503573 | 0.84 | BACE1 (0.51) | DHFRBACE1SCN5ASCN9APIK3R1 | |
| SCHEMBL4524134 | 0.83 | CYP1A2 (0.57) | DHFRBACE1SCN5ASCN9APIK3R1 | |
| SCHEMBL4528905 | 0.83 | PTPN1 (0.62) | DHFRBACE1PIK3R1PIK3CATRPA1 | |
| SCHEMBL8512311 | 0.81 | DHFR (1.00) | DHFRMAP4K4DCPS | |
| SCHEMBL3735069 | 0.79 | BACE1 (0.60) | BACE1SCN9APIK3R1PIK3CAALOX5AP | |
| SCHEMBL4528846 | 0.79 | PTPN1 (0.66) | DHFRBACE1SCN5ASCN9A | |
| SCHEMBL4516307 | 0.78 | DHFR (0.73) | DHFRBACE1MAP4K4DCPS | |
| SCHEMBL5503577 | 0.77 | TRPA1 (0.49) | DHFRBACE1PIK3R1PIK3CATRPA1 | |
| Trifluoroacetic Acid SCHEMBL4527702 | 0.77 | CYP2D6 (0.51) | DHFRBACE1SCN5ASCN9APIK3R1 | |
| SCHEMBL9605513 | 0.76 | DHFR (1.00) | DHFRMAP4K4DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | BERTHEL STEVEN JOSEPH | 2009-04-23 | — | — | US | disclosed |
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | disclosed |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2006-09-21 | — | — | US | disclosed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105477-A1 | Quinazoline Protein Tyrosine Phosphatase Inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885BACE1 3629/4885MAP4K4 639/4885 |
| US-20060211715-A1 | Quinazoline protein tyrosine phosphatase inhibitors | PTPN5, PTPN1, PTPN7 | DHFR 2071/4885BACE1 3629/4885MAP4K4 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.