Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 6/20 | 0.64 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493922 | 0.84 | TBXAS1 (0.55) | TBXAS1TUBB1KDM4EPKMLMNA | |
| SCHEMBL5502664 | 0.76 | KDM4E (0.44) | KDM4EPKMLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL873953 | 0.76 | KDM4E (0.53) | KDM4ELMNAKMT2AHTTSMN1; SMN2 | |
| SCHEMBL27905206 | 0.75 | KDM4E (0.51) | TUBB1KDM4ELMNAKMT2AHTT | |
| SCHEMBL17922746 | 0.75 | KDM4E (0.51) | KDM4ELMNAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL19405222 | 0.75 | KDM4E (0.51) | KDM4ELMNAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL15595723 | 0.74 | TBXAS1 (0.64) | TBXAS1TUBB1KDM4EPKMLMNA | |
| SCHEMBL348568 | 0.74 | KDM4E (0.69) | KDM4ELMNAKMT2AHTTPOLB | |
| Hydrochloric Acid SCHEMBL30949462 | 0.74 | TBXAS1 (0.65) | TBXAS1TUBB1KDM4EPKMLMNA | |
| SCHEMBL15595727 | 0.74 | TBXAS1 (0.55) | TBXAS1TUBB1KDM4EPKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |