Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502741 | 0.84 | TBXAS1 (0.64) | TBXAS1LMNAKDM4ETUBB1PKM | |
| SCHEMBL5499495 | 0.79 | L3MBTL1 (0.56) | ALDH1A1LMNAL3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL873870 | 0.79 | POLB (0.53) | ALDH1A1LMNAL3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL348156 | 0.77 | LMNA (0.57) | ALDH1A1LMNAKDM4EL3MBTL1PKM | |
| SCHEMBL2927309 | 0.76 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL15966774 | 0.75 | HTT (0.47) | ALDH1A1LMNAKDM4EL3MBTL1PKM | |
| SCHEMBL8179907 | 0.74 | LMNA (0.43) | ALDH1A1LMNAL3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL5499989 | 0.73 | KDM4E (0.57) | ALDH1A1LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL6532154 | 0.73 | KDM4E (0.57) | ALDH1A1LMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL17826563 | 0.71 | ALDH1A1 (0.68) | ALDH1A1LMNAKDM4EPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |