Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994515 | 0.98 | HPGD (0.41) | HPGDKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL208153 | 0.95 | USP5 (0.39) | USP5HDAC6PTPRCCTSLPTPN13 | |
| SCHEMBL209957 | 0.86 | USP5 (0.40) | USP5HDAC6PTPRCCTSLPTPN13 | |
| SCHEMBL2999256 | 0.85 | PDE4D (0.41) | PDE1APDE1BPDE4DPDE7APDE1C | |
| SCHEMBL210127 | 0.85 | CXCR4 (0.38) | KMT2APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL5503535 | 0.83 | MAPK14 (0.43) | HPGDSMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL5503539 | 0.83 | NPC1 (0.38) | SMN1; SMN2MEN1KMT2ABCL2L1MCL1 | |
| Hydrochloric Acid SCHEMBL5503572 | 0.83 | NPC1 (0.37) | SMN1; SMN2MEN1KMT2ABCL2L1MCL1 | |
| Hydrochloric Acid SCHEMBL5503567 | 0.83 | MAPK14 (0.43) | HPGDSMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL2988655 | 0.82 | PDE4D (0.38) | ALDH1A1PDE1APDE1BPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |