Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5503572 | 0.99 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL4062034 | 0.92 | HTT (0.37) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL2999256 | 0.86 | PDE4D (0.41) | NPC1RAB9AERN1 | |
| SCHEMBL5503535 | 0.86 | MAPK14 (0.43) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL2994515 | 0.85 | HPGD (0.41) | SMN1; SMN2BCL2L1MCL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5503567 | 0.85 | MAPK14 (0.43) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL5502865 | 0.83 | HPGD (0.41) | SMN1; SMN2BCL2L1MCL1MEN1KMT2A | |
| SCHEMBL4063694 | 0.83 | HTT (0.39) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL4064162 | 0.81 | HTT (0.36) | NPC1RAB9ASMN1; SMN2HTTCNR2 | |
| SCHEMBL3000225 | 0.81 | USP30 (0.35) | CNR2BCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |