Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5503567 | 0.99 | MAPK14 (0.43) | MAPK14MAPK8MAPK10RAB9ANPC1 | |
| SCHEMBL4062030 | 0.92 | CNR2 (0.41) | RAB9ANPC1CNR2SMYD3SMN1; SMN2 | |
| SCHEMBL2999256 | 0.88 | PDE4D (0.41) | RAB9ANPC1ERN1 | |
| Trifluoroacetic Acid SCHEMBL5504877 | 0.87 | HDAC4 (0.41) | RAB9ANPC1CNR2SMYD3SMN1; SMN2 | |
| SCHEMBL5503539 | 0.86 | NPC1 (0.38) | MAPK14RAB9ANPC1ERN1CNR2 | |
| SCHEMBL2994515 | 0.85 | HPGD (0.41) | SMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL5503572 | 0.85 | NPC1 (0.37) | MAPK14RAB9ANPC1ERN1CNR2 | |
| SCHEMBL5502865 | 0.83 | HPGD (0.41) | ROCK2ROCK1SMN1; SMN2HPGD | |
| SCHEMBL4063688 | 0.83 | SMYD3 (0.41) | RAB9ANPC1CNR2SMYD3SMN1; SMN2 | |
| SCHEMBL3000225 | 0.81 | USP30 (0.35) | L3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |