Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.38 |
| ▸ | DRD3 | P35462 | 12/20 | 0.38 |
| ▸ | HTR2A | P28223 | 8/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 7/20 | 0.34 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500490 | 0.95 | DRD4 (0.34) | DRD2DRD3HTR2AHRH1HTR1A | |
| SCHEMBL5503773 | 0.92 | DRD2 (0.37) | DRD2DRD3HTR2AHRH1HTR1A | |
| SCHEMBL2782274 | 0.83 | DRD2 (0.47) | DRD2DRD3HTR2AHRH1HTR1A | |
| SCHEMBL5525414 | 0.83 | DRD2 (0.39) | DRD2DRD3HTR2AHRH1HTR1A | |
| SCHEMBL2781886 | 0.81 | MAPT (0.41) | DRD2DRD3HTR2AHRH1DRD4 | |
| SCHEMBL5503520 | 0.81 | DRD2 (0.40) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL2783918 | 0.80 | DRD2 (0.44) | DRD2DRD3HTR2AHRH1DRD4 | |
| SCHEMBL2781778 | 0.80 | DRD2 (0.46) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL2782453 | 0.79 | DRD2 (0.44) | DRD2DRD3DRD4 | |
| SCHEMBL2783702 | 0.79 | DRD2 (0.41) | DRD2DRD3HTR2AHRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |