Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | CA2 | P00918 | 6/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699710 | 0.78 | AKR1C2 (0.46) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL7073697 | 0.77 | CA1 (0.37) | CA1CA2CA9CA12POLB | |
| SCHEMBL5498679 | 0.76 | TBXAS1 (0.47) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL5503081 | 0.75 | PTPN5 (0.41) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL5500896 | 0.75 | PTPN5 (0.41) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL5495626 | 0.74 | PTPN5 (0.39) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL5500665 | 0.74 | PTPN5 (0.41) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL5496404 | 0.74 | PTPN5 (0.39) | PTPN5PDE3BPDE3ATUBB4ATUBB | |
| SCHEMBL7931226 | 0.72 | MME (0.40) | PTPN5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5502919 | 0.71 | PTPN5 (0.36) | PTPN5PDE3BPDE3ATUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146789-A4 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RES FOUNDATION INC (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1146789-A1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RESEARCH FOUNDATION, INC. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044225-A1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/neu | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-08-03 | — | — | WO | disclosed |