Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074273 | 0.80 | MDM2 (0.40) | MDM2KDM4AKDM5AKDM5B | |
| SCHEMBL5503145 | 0.77 | PTPN5 (0.37) | CA1CA2CA9CA12POLB | |
| SCHEMBL7072708 | 0.67 | GPR17 (0.61) | MAPTMDM2POLBCCR2MEN1 | |
| SCHEMBL7842628 | 0.64 | KDM4E (0.47) | MAPTMDM2POLB | |
| SCHEMBL7817673 | 0.64 | MCL1 (0.48) | — | |
| SCHEMBL6996736 | 0.62 | ALDH1A1 (0.52) | CA1CA2CA9CA12MEN1 | |
| SCHEMBL6996735 | 0.62 | ALDH1A1 (0.52) | CA1CA2CA9CA12MEN1 | |
| SCHEMBL6302418 | 0.62 | ABCB11 (0.55) | MAPTLMNACCR2MEN1KMT2A | |
| SCHEMBL6302422 | 0.62 | ABCB11 (0.55) | MAPTLMNACCR2MEN1KMT2A | |
| SCHEMBL6594503 | 0.62 | MAPT (0.47) | MAPTPOLBLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |