Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL17627367 | 0.95 | TSHR (0.40) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Propylene Glycol SCHEMBL155544 | 0.95 | TSHR (0.40) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL4591928 | 0.87 | TSHR (0.42) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Isopropyl Alcohol SCHEMBL28434694 | 0.87 | TSHR (0.45) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL60590 | 0.87 | TSHR (0.48) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Methyl Alcohol SCHEMBL3842813 | 0.85 | TSHR (0.47) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL7160598 | 0.84 | TSHR (0.42) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL155545 | 0.83 | HSD17B10 (0.42) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Propylene Glycol SCHEMBL701829 | 0.82 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| Propylene Glycol SCHEMBL27975974 | 0.82 | TSHR (0.44) | TSHRCHRM2CHRM4CHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816899-B1 | Color filter and black resist composition | MITSUBISHI CHEM CORP (JP) | 2007-09-26 | — | — | EP | disclosed |
| US-5914206-A | RESIN BLACK MATRIX HAS A 20.DEGREE. SPECULAR GLOSSINESS OF FROM 100 TO 200. | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-06-22 | — | — | US | disclosed |
| EP-0816899-A2 | Color filter and black resist composition | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-01-07 | — | — | EP | disclosed |