Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6009391 | 0.87 | SCN8A (0.49) | SLC6A5HDAC1HDAC8RORC | |
| SCHEMBL9957835 | 0.84 | HDAC1 (0.51) | KMT2AHDAC1HDAC8TAAR1 | |
| SCHEMBL5500210 | 0.83 | KDM4E (0.49) | MEN1KMT2AHDAC1HDAC8CNR1 | |
| SCHEMBL5504458 | 0.83 | CA12 (0.50) | TAAR1SIGMAR1KDM4E | |
| SCHEMBL918611 | 0.80 | CA12 (0.50) | KMT2ATAAR1SIGMAR1 | |
| SCHEMBL31618076 | 0.80 | TAAR1 (0.47) | MEN1KMT2ASLC6A5HDAC1HDAC8 | |
| SCHEMBL5509232 | 0.77 | CHRM2 (0.50) | HDAC1HDAC8SIGMAR1 | |
| SCHEMBL5775963 | 0.77 | MEN1 (0.54) | MEN1KMT2AKDM4E | |
| SCHEMBL4655812 | 0.76 | TAAR1 (0.50) | MEN1KMT2ASLC6A5HDAC1HDAC8 | |
| SCHEMBL6009871 | 0.75 | CA1 (0.44) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828111-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006059252-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-06-08 | — | — | WO | disclosed |