Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.41 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SPOP | O43791 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503292 | 1.00 | TDP1 (0.45) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5502011 | 0.90 | CA5A (0.50) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5502024 | 0.90 | CA5A (0.50) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5507779 | 0.88 | NAPEPLD (0.56) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5507770 | 0.88 | NAPEPLD (0.56) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5510593 | 0.88 | CA5A (0.60) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5510598 | 0.88 | CA5A (0.60) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5510443 | 0.86 | CA5A (0.45) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5510426 | 0.86 | CA5A (0.45) | TDP1MAPTPOLBPKMHTT | |
| SCHEMBL5506499 | 0.86 | TDP1 (0.46) | TDP1MAPTPOLBPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |