Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.85 |
| ▸ | HTT | P42858 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 1/20 | 0.85 |
| ▸ | AR | P10275 | 8/20 | 0.81 |
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | GALR3 | O60755 | 1/20 | 0.70 |
| ▸ | STAT3 | P40763 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155143 | 0.89 | AR (1.00) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL15501211 | 0.88 | NPC1 (0.74) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL5114943 | 0.87 | AR (1.00) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL425175 | 0.84 | RAB9A (1.00) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL15329956 | 0.84 | AR (0.74) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL2948524 | 0.83 | RAB9A (0.91) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL9729274 | 0.82 | NPC1 (0.88) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL21639229 | 0.82 | NPC1 (0.88) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL11535096 | 0.82 | NPC1 (0.88) | LMNAMAPTKMT2AHTTMEN1 | |
| SCHEMBL8098342 | 0.81 | RAB9A (0.82) | LMNAMAPTKMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | claimed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | claimed |