Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700804 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR1HCRTR2ARGRM5 | |
| SCHEMBL2700806 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR1HCRTR2ARGRM5 | |
| SCHEMBL550358 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR1HCRTR2ARGRM5 | |
| SCHEMBL550482 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR1HCRTR2ARGRM5 | |
| SCHEMBL550483 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR1HCRTR2ARGRM5 | |
| SCHEMBL550943 | 0.88 | HSD11B1 (0.39) | HSD11B1HCRTR1HCRTR2GRM5HTR1A | |
| SCHEMBL2699861 | 0.88 | HSD11B1 (0.39) | HSD11B1HCRTR1HCRTR2GRM5HTR1A | |
| SCHEMBL17082093 | 0.87 | HSD11B1 (0.35) | HSD11B1AR | |
| SCHEMBL550210 | 0.87 | HSD11B1 (0.35) | HSD11B1AR | |
| SCHEMBL4572368 | 0.87 | HSD11B1 (0.35) | HSD11B1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |