Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493668 | 0.80 | OPRM1 (0.50) | OPRM1OPRK1OPRL1ADRA1DADRA1B | |
| SCHEMBL5386780 | 0.80 | OPRM1 (0.49) | OPRM1OPRK1OPRL1ADRA1DADRA1B | |
| SCHEMBL5396966 | 0.79 | OPRM1 (0.51) | OPRM1OPRK1OPRL1ADRA1DADRA1B | |
| SCHEMBL5396910 | 0.77 | OPRM1 (0.52) | OPRM1OPRK1OPRL1ADRA1DADRA1B | |
| SCHEMBL5396316 | 0.75 | DRD2 (0.57) | OPRM1OPRK1OPRL1ADRA1DADRA1B | |
| SCHEMBL5389384 | 0.74 | OPRM1 (0.56) | OPRM1OPRK1OPRL1ADRA1DSLC6A4 | |
| SCHEMBL5384939 | 0.73 | OPRM1 (0.59) | OPRM1OPRK1OPRL1ADRA1DCCR2 | |
| SCHEMBL5387677 | 0.73 | OPRM1 (0.58) | OPRM1OPRK1OPRL1ADRA1DCCR2 | |
| SCHEMBL5387404 | 0.72 | OPRM1 (0.60) | OPRM1OPRK1OPRL1ADRA1DCCR2 | |
| SCHEMBL5388923 | 0.72 | OPRM1 (0.50) | OPRM1OPRK1OPRL1ADRA1DCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468996-B1 | Indole derivatives for the treatment of CNS disorders | LUNDBECK & CO AS H (DK) | 2007-09-26 | — | — | EP | claimed |