Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506480 | 0.95 | DRD2 (0.42) | DRD2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL5509179 | 0.94 | ADRA2A (0.43) | DRD2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL5506603 | 0.89 | DRD2 (0.38) | DRD2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL3768142 | 0.89 | ADRA2A (0.48) | DRD2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL5503228 | 0.88 | DRD2 (0.43) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL5503775 | 0.88 | DRD2 (0.43) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL3772530 | 0.87 | DRD2 (0.58) | DRD2SLC6A4DRD3 | |
| SCHEMBL3766154 | 0.85 | MEN1 (0.45) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL5505004 | 0.84 | DRD2 (0.41) | DRD2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL5506620 | 0.84 | DRD2 (0.44) | DRD2SLC6A4DRD3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768958-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-04 | — | — | EP | claimed |
| WO-2005121088-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |