SCHEMBL5503877

SCHEMBL5503877

COc1ccc2nccc(CCO)c2c1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.66
MTNR1B P49286 3/20 0.66
ROCK2 O75116 1/20 0.56
LMNA P02545 1/20 0.55
KDM4E B2RXH2 2/20 0.54
HTR1A P08908 1/20 0.52
ADRA1D P25100 1/20 0.52
ADRA1A P35348 1/20 0.52
ADRA1B P35368 1/20 0.52
MAPK1 P28482 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
CYP2D6 P10635 1/20 0.51
CYP1A2 P05177 1/20 0.51
KCNH2 Q12809 2/20 0.47
CYP19A1 P11511 1/20 0.46
SLC22A12 Q96S37 1/20 0.46
RIPK2 O43353 1/20 0.46
KDR P35968 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20542004 0.91 MTNR1A (0.63) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL2544860 0.88 MTNR1A (0.61) MTNR1AMTNR1BROCK2LMNAKDM4E
Bromide SCHEMBL30402372 0.86 MTNR1A (0.60) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL2095741 0.86 MTNR1A (0.67) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL6378710 0.85 MTNR1A (0.62) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL591578 0.85 MTNR1A (0.62) MTNR1AMTNR1BROCK2LMNAKDM4E
Hydrochloric Acid SCHEMBL30420837 0.85 MTNR1A (0.59) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL5004426 0.84 MTNR1A (0.62) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL592246 0.83 MTNR1A (0.67) MTNR1AMTNR1BROCK2LMNAKDM4E
SCHEMBL4081621 0.83 MTNR1A (0.64) MTNR1AMTNR1BROCK2LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1359908-A1 QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM PLC (GB) 2003-11-12 EP claimed
WO-2002056882-A1 QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-25 WO claimed
EP-1799676-A2 NEW BICYCLIC ANTIBIOTICS Actelion Pharmaceuticals Ltd. (CH) 2007-06-27 EP disclosed
WO-2006032466-A2 NEW BICYCLIC ANTIBIOTICS ACTELION PHARMACEUTICALS LTD (CH) 2006-03-30 WO disclosed