Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503877 | 0.91 | MTNR1A (0.66) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL2544860 | 0.85 | MTNR1A (0.61) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL2095741 | 0.84 | MTNR1A (0.67) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| Bromide SCHEMBL30402372 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL6378710 | 0.82 | MTNR1A (0.62) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL591578 | 0.82 | MTNR1A (0.62) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL30420837 | 0.82 | MTNR1A (0.59) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL15453205 | 0.82 | MTNR1A (0.59) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL5004426 | 0.82 | MTNR1A (0.62) | MTNR1AMTNR1BROCK2HTR1AADRA1D | |
| SCHEMBL6559028 | 0.81 | MTNR1B (0.86) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352349-B2 | Type II topoisomerase inhibitors and methods of making and using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-11352349-B2 | Type II topoisomerase inhibitors and methods of making and using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200131158-A1 | TYPE II TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2020-04-30 | — | — | US | disclosed |
| US-20200131158-A1 | TYPE II TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2020-04-30 | — | — | US | disclosed |
| EP-3612513-A1 | TYPE II TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | Ohio State Innovation Foundation (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2018195098-A1 | TYPE II TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2018-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352349-B2 | Type II topoisomerase inhibitors and methods of making and using thereof | TOP2A, TOP1, TOP2B | MTNR1A 4171/4885MTNR1B 3974/4885ROCK2 511/4885 |
| US-20200131158-A1 | TYPE II TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | TOP2A, TOP1, TOP2B | MTNR1A 4171/4885MTNR1B 3974/4885ROCK2 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.