Biotin

Biotin

SCHEMBL5503948

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CC(O)C(=O)N1

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 0.76
MEN1 O00255 1/20 0.76
ABL1 P00519 1/20 0.76
LMNA P02545 1/20 0.76
PKM P14618 1/20 0.76
IDE P14735 1/20 0.76
MAPK1 P28482 1/20 0.76
KMT2A Q03164 1/20 0.76
RIN1 Q13671 1/20 0.76
L3MBTL1 Q9Y468 1/20 0.76
HLCS P50747 6/20 0.54
CA12 O43570 5/20 0.46
CA1 P00915 5/20 0.46
CA2 P00918 5/20 0.46
CA9 Q16790 5/20 0.46
PTPRF P10586 2/20 0.44
PTPN2 P17706 2/20 0.44
PTPN1 P18031 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL2456558 1.00 TDP1 (0.76) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL9841217 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL410686 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL7697731 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL59420 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL23055065 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL21981206 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL22943835 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL20547409 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL36572 0.87 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105814213-B Modified glycoproteins, protein-conjugates and methods of making the same 西纳福克斯股份有限公司 2021-05-04 CN disclosed
US-20190307903-A1 METHOD FOR MANUFACTURING A BIOCOMPATIBLE FLUID COMPRISING A POWDER OF MAGNETIC PARTICLES, BIOCOMPATIBLE FLUID COMPRISING A POWDER OF MAGNETIC PARTICLES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2019-10-10 US disclosed
EP-3549577-A1 METHOD FOR MANUFACTURING A BIOCOMPATIBLE FLUID COMPRISING A MAGNETIC PARTICLE POWDER, BIOCOMPATIBLE FLUID COMPRISING A MAGNETIC PARTICLE POWDER Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) 2019-10-09 EP disclosed
US-10081678-B2 Specific binding antibodies of glycoprotein IB alpha as selective ectodomain shedding inhibitors EMORY UNIVERSITY (US) 2018-09-25 US disclosed
US-20160009801-A1 SPECIFIC BINDING AGENTS OF GLYCOPROTEIN IB ALPHA AS SELECTIVE ECTODOMAIN SHEDDING INHIBITORS EMORY UNIVERSITY 2016-01-14 US disclosed
EP-2890788-A1 BIOTIN COMPLEXES FOR TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE The General Hospital Corporation (US) 2015-07-08 EP disclosed
WO-2014121176-A2 SPECIFIC BINDING AGENTS OF GLYCOPROTEIN IB ALPHA AS SELECTIVE ECTODOMAIN SHEDDING INHIBITORS EMORY UNIVERSITY (US) 2014-08-07 WO disclosed
WO-2014036427-A1 BIOTIN COMPLEXES FOR TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE THE GENERAL HOSPITAL CORPORATION (US) 2014-03-06 WO disclosed
EP-1634077-A4 MICROPOSITIONING CELLS FOR TISSUE ENGINEERING UNIV TEXAS (US) 2007-03-28 EP disclosed
WO-2006124726-A2 NOVEL BIOTINYLATED COMPOSITIONS THE GENERAL HOSPITAL CORPORATION (US) 2006-11-23 WO disclosed
US-20020142389-A1 Soluble T cell receptor JAKOBSEN BENT KARSTEN (GB) 2002-10-03 US disclosed
US-20020119149-A1 Multivalent T cell receptor complexes JAKOBSEN BENT KARSTEN (GB) 2002-08-29 US disclosed
WO-2002058729-A2 METHODS OF INDUCING ORGAN TRANSPLANT TOLERANCE AND CORRECTING HEMOGLOBINOPATHIES EMORY UNIVERSITY (US) 2002-08-01 WO disclosed
EP-1066380-B1 SOLUBLE T CELL RECEPTOR AVIDEX LTD (GB) 2001-11-14 EP disclosed
EP-1080193-A2 MULTIVALENT T CELL RECEPTOR COMPLEXES Avidex, Ltd. (GB) 2001-03-07 EP disclosed
EP-1066380-A2 SOLUBLE T CELL RECEPTOR Avidex Ltd. (GB) 2001-01-10 EP disclosed
WO-1999060119-A2 MULTIVALENT T CELL RECEPTOR COMPLEXES AVIDEX, LTD. (GB) 1999-11-25 WO disclosed
WO-1999060120-A2 SOLUBLE T CELL RECEPTOR AVIDEX LIMITED (GB) 1999-11-25 WO disclosed
EP-0654061-A1 A METHOD OF CHEMICAL COUPLING ON SOLID PHASES MOURITSEN & ELSNER A/S (DE) 1995-05-24 EP disclosed
WO-1994003530-A1 A METHOD OF CHEMICAL COUPLING ON SOLID PHASES MOURITSEN & ELSNER A/S (DK) 1994-02-17 WO disclosed