Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788153 | 1.00 | KMT2A (0.37) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL2788151 | 0.80 | HPGD (0.40) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL4473715 | 0.80 | HPGD (0.40) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL2570052 | 0.71 | DAO (0.40) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL2566643 | 0.66 | SMN1; SMN2 (0.40) | KMT2ARAB9AMEN1SMN1; SMN2HTT | |
| SCHEMBL2570050 | 0.64 | HPGD (0.43) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL2567760 | 0.64 | POLB (0.43) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL3028244 | 0.64 | KMT2A (0.42) | KMT2ARAB9AMEN1SMN1; SMN2GAA | |
| SCHEMBL3744066 | 0.63 | P2RX7 (0.63) | — | |
| SCHEMBL2566849 | 0.63 | SMN1; SMN2 (0.41) | KMT2ARAB9AMEN1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747217-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005111029-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |