Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473715 | 1.00 | HPGD (0.40) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL5503969 | 0.80 | KMT2A (0.37) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL2788153 | 0.80 | KMT2A (0.37) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL6454350 | 0.74 | F10 (0.39) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL13165794 | 0.72 | HDAC3 (0.39) | LMNAKMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2570050 | 0.69 | HPGD (0.43) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL5111694 | 0.67 | DAO (0.46) | HPGDLMNAKMT2ARAB9AMEN1 | |
| SCHEMBL10145336 | 0.66 | CHRNB2 (0.35) | LMNAHTTALDH1A1NFKB1 | |
| SCHEMBL9457850 | 0.66 | ALDH1A1 (0.44) | GAAALDH1A1TSHR | |
| SCHEMBL3744066 | 0.65 | P2RX7 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |