Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13045357 | 0.79 | KMT2A (0.62) | MAPTEPHX2ALDH1A1CA1CA2 | |
| SCHEMBL7702998 | 0.78 | MAPT (0.59) | MAPTPLCG1TDP1RECQLALDH1A1 | |
| SCHEMBL15916526 | 0.76 | MAPT (0.97) | MAPTHTR1AHTR7EPHX2RECQL | |
| SCHEMBL15915230 | 0.74 | MAPT (1.00) | MAPTHTR1AHTR7EPHX2RECQL | |
| SCHEMBL15916076 | 0.74 | MAPT (0.56) | MAPTPLCG1TDP1RECQLALDH1A1 | |
| SCHEMBL2494822 | 0.72 | TDP1 (0.51) | MAPTHTR1AHTR7PLCG1TDP1 | |
| SCHEMBL15915182 | 0.71 | MAPT (0.87) | MAPTHTR1AHTR7PLCG1RECQL | |
| SCHEMBL3406883 | 0.70 | GBA1 (0.60) | MAPTPLCG1TDP1RECQLALDH1A1 | |
| SCHEMBL4873735 | 0.69 | MMP1 (0.52) | EPHX2ALDH1A1POLBCA1CA2 | |
| SCHEMBL4001281 | 0.68 | MAPT (0.60) | MAPTHTR1AHTR7EPHX2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |