Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | PARG | Q86W56 | 1/20 | 0.43 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AQP1 | P29972 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15916076 | 0.95 | MAPT (0.56) | MAPTBCL2L1MCL1GBA1KMT2A | |
| SCHEMBL3406883 | 0.92 | GBA1 (0.60) | MAPTGBA1RECQLALDH1A1POLB | |
| SCHEMBL14606680 | 0.85 | GBA1 (0.53) | MAPTGBA1RECQLALDH1A1POLB | |
| SCHEMBL11705019 | 0.82 | NPY5R (0.62) | MAPTBCL2L1MCL1GBA1KMT2A | |
| SCHEMBL15916929 | 0.82 | POLB (0.50) | MAPTGBA1KMT2ARECQLALDH1A1 | |
| SCHEMBL13797033 | 0.80 | GBA1 (0.47) | MAPTGBA1RECQLALDH1A1POLB | |
| SCHEMBL5164880 | 0.78 | PI4KB (0.53) | BCL2L1MCL1GBA1KMT2AALDH1A1 | |
| SCHEMBL5167099 | 0.78 | PI4KB (0.53) | BCL2L1MCL1GBA1KMT2AALDH1A1 | |
| SCHEMBL5504040 | 0.78 | MAPT (0.58) | MAPTRECQLALDH1A1POLBPLCG1 | |
| SCHEMBL7886816 | 0.78 | GBA1 (0.83) | BCL2L1MCL1GBA1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109441-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| WO-2002057220-A1 | HYDRAZIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2002-07-25 | — | — | WO | disclosed |