Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 2/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5499839 | 0.99 | CNR1 (0.36) | CNR1PDCD1LG2CD274KDM4EGBA1 | |
| SCHEMBL5503412 | 0.89 | PDCD1LG2 (0.33) | PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5504025 | 0.88 | PDCD1LG2 (0.33) | PDCD1LG2CD274 | |
| SCHEMBL5499996 | 0.86 | CNR1 (0.38) | CNR1KDM4ECYP11B2CYP11B1CCR5 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.85 | CNR1 (0.38) | CNR1KDM4ECYP11B2CYP11B1CCR5 | |
| SCHEMBL5500821 | 0.84 | CNR1 (0.38) | CNR1CYP11B2PIM1CYP11B1CCR5 | |
| SCHEMBL5504883 | 0.84 | CYP11B2 (0.35) | CNR1PDCD1LG2CD274KDM4EGBA1 | |
| Hydrochloric Acid SCHEMBL5503796 | 0.83 | CYP11B2 (0.34) | CNR1PDCD1LG2CD274KDM4EGBA1 | |
| SCHEMBL5504107 | 0.82 | CYP11B2 (0.41) | CNR1KDM4ECYP11B2PIM1CYP11B1 | |
| Hydrochloric Acid SCHEMBL5504176 | 0.81 | CYP11B2 (0.40) | CNR1KDM4ECYP11B2PIM1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |