Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 4/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5503796 | 0.99 | CYP11B2 (0.34) | CYP11B2CNR1CNR2LDHACYP11B1 | |
| SCHEMBL5503476 | 0.89 | PDCD1LG2 (0.32) | CNR2LDHAPDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5505492 | 0.88 | PDCD1LG2 (0.31) | LDHAPDCD1LG2CD274 | |
| SCHEMBL5504107 | 0.86 | CYP11B2 (0.41) | CYP11B2CNR1CYP11B1KDM4ECCR5 | |
| Hydrochloric Acid SCHEMBL5504176 | 0.85 | CYP11B2 (0.40) | CYP11B2CNR1CYP11B1KDM4ECCR5 | |
| SCHEMBL5506971 | 0.85 | CNR2 (0.32) | CNR2PDCD1LG2CD274 | |
| SCHEMBL5504170 | 0.84 | CNR1 (0.36) | CYP11B2CNR1CYP11B1KDM4EPDCD1LG2 | |
| Hydrochloric Acid SCHEMBL5499839 | 0.83 | CNR1 (0.36) | CYP11B2CNR1CYP11B1KDM4EPDCD1LG2 | |
| SCHEMBL5504207 | 0.82 | MEN1 (0.33) | PDCD1LG2CD274 | |
| SCHEMBL5499996 | 0.81 | CNR1 (0.38) | CYP11B2CNR1CYP11B1KDM4ECYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |