Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14527259 | 0.84 | NPC1 (0.72) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL27876288 | 0.82 | RAB9A (0.70) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL12387872 | 0.81 | RAB9A (0.73) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL18254456 | 0.81 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL30592065 | 0.81 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL17087710 | 0.81 | NPC1 (0.75) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL17236166 | 0.80 | SMN1; SMN2 (0.77) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL15426715 | 0.80 | NPC1 (0.74) | RAB9ANPC1POLBSMN1; SMN2LMNA | |
| SCHEMBL8970331 | 0.79 | MAPT (0.65) | RAB9ANPC1POLBGAAKDM4E | |
| SCHEMBL4652925 | 0.78 | SMN1; SMN2 (0.71) | RAB9ANPC1POLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006028904-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-03-16 | — | — | WO | disclosed |