SCHEMBL5504494

SCHEMBL5504494

NC(=O)Cc1ccccc1-c1ccc2c(c1)Sc1ccccc1N2C1CCN(Cc2ccccn2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
PARP1 P09874 2/20 0.41
KDM4E B2RXH2 4/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
OPRM1 P35372 1/20 0.38
DRD4 P21917 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
POLB P06746 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
GSK3B P49841 1/20 0.37
SIGMAR1 Q99720 1/20 0.36
F2 P00734 1/20 0.36
F10 P00742 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5500227 0.84 PARP1 (0.41) HRH3PARP1KDM4ESMN1; SMN2DRD4
SCHEMBL5115636 0.83 HRH3 (0.41) HRH3L3MBTL1PARP1KDM4ESMN1; SMN2
SCHEMBL5503601 0.81 HRH3 (0.36) HRH3SMN1; SMN2ALDH1A1MAPTTSHR
SCHEMBL5507817 0.81 L3MBTL1 (0.51) HRH3L3MBTL1PARP1KDM4ESMN1; SMN2
SCHEMBL5112936 0.79 DRD2 (0.40) HRH3L3MBTL1KDM4ESMN1; SMN2DRD4
SCHEMBL5118837 0.78 L3MBTL1 (0.43) HRH3L3MBTL1PARP1KDM4ESMN1; SMN2
SCHEMBL5114019 0.77 HRH3 (0.38) HRH3L3MBTL1PARP1KDM4ESMN1; SMN2
SCHEMBL5112122 0.76 CHRM1 (0.46) HRH3L3MBTL1KDM4ESMN1; SMN2OPRM1
SCHEMBL5112751 0.75 HRH3 (0.45) HRH3L3MBTL1KDM4ESMN1; SMN2DRD4
SCHEMBL5513194 0.73 L3MBTL1 (0.46) HRH3L3MBTL1PARP1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP disclosed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO disclosed