Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511426 | 0.94 | HTR1A (0.37) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL1037492 | 0.78 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL1037712 | 0.77 | HTR1A (0.56) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL4630514 | 0.76 | DRD2 (0.33) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL5506910 | 0.73 | MAP2K1 (0.44) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL5508733 | 0.73 | DRD2 (0.45) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL4630605 | 0.73 | HTR1A (0.33) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL5502282 | 0.72 | DRD2 (0.43) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL20915099 | 0.72 | DRD2 (0.46) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| Hydrochloric Acid SCHEMBL5512177 | 0.72 | DRD2 (0.42) | HTR1ADRD2HTR2AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869025-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006112464-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |