Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 11/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.49 |
| ▸ | JAK3 | P52333 | 9/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504527 | 0.91 | KDR (0.52) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5498528 | 0.90 | KDR (0.57) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5498705 | 0.86 | LCK (0.55) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5498060 | 0.82 | MAPK14 (0.58) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5499158 | 0.80 | KDR (0.56) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5501153 | 0.79 | LCK (0.52) | KDRBRAFLCKMAPK14JAK3 | |
| SCHEMBL5498136 | 0.79 | LCK (0.64) | KDRBRAFLCKMAPK14JAK3 | |
| SCHEMBL14715520 | 0.79 | KDR (0.51) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL5503952 | 0.77 | KDR (0.53) | KDRBRAFKRASRAF1LCK | |
| SCHEMBL23745196 | 0.75 | ABL1 (0.57) | KDRBRAFKRASRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | KDR 1044/4885BRAF 100/4885KRAS 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.