Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.52 |
| ▸ | LCK | P06239 | 15/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | KRAS | P01116 | 3/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 12/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ARAF | P10398 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | CSK | P41240 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504532 | 0.91 | KDR (0.50) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5498528 | 0.88 | KDR (0.57) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5498705 | 0.81 | LCK (0.55) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5498060 | 0.79 | MAPK14 (0.58) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5498719 | 0.76 | LCK (0.79) | KDRMAPK14LCKBRAFJAK3 | |
| SCHEMBL5502584 | 0.76 | KDR (0.79) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5502277 | 0.74 | KDM4E (0.54) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL21416842 | 0.74 | LCK (0.67) | KDRMAPK14LCKBRAFJAK3 | |
| SCHEMBL14715520 | 0.73 | KDR (0.51) | KDRMAPK14LCKBRAFKRAS | |
| SCHEMBL5499229 | 0.73 | ALDH1A1 (0.52) | KDRMAPK14LCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | KDR 1044/4885MAPK14 301/4885LCK 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.