Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12949528 | 0.90 | GBA1 (0.58) | GBA1TBXAS1LMNAMAPTNPSR1 | |
| SCHEMBL5502574 | 0.86 | MAPT (0.59) | TBXAS1LMNAMAPTNPSR1MEN1 | |
| SCHEMBL5508771 | 0.86 | MAPT (0.59) | TBXAS1LMNAMAPTNPSR1MEN1 | |
| SCHEMBL5503986 | 0.81 | TP53 (0.56) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL27287741 | 0.79 | GRIA4 (0.56) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL6179006 | 0.79 | GRIA4 (0.56) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL6992717 | 0.78 | SMN1; SMN2 (0.51) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4415272 | 0.77 | GRIA4 (0.40) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL5508754 | 0.74 | TP53 (0.54) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL6987199 | 0.73 | KMT2A (0.45) | LMNAMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |