Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508754 | 0.93 | TP53 (0.54) | TP53LMNANPSR1ALDH1A1MAPT | |
| SCHEMBL5504602 | 0.81 | MMP1 (0.49) | LMNANPSR1MAPTKMT2ACYP19A1 | |
| SCHEMBL3188111 | 0.70 | TP53 (0.45) | TP53ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL12949528 | 0.70 | GBA1 (0.58) | TP53LMNANPSR1ALDH1A1MAPT | |
| SCHEMBL21225933 | 0.69 | MMP2 (0.50) | TP53ALDH1A1CYP19A1GAAMMP1 | |
| SCHEMBL3203039 | 0.68 | TP53 (0.43) | TP53NPSR1ALDH1A1KMT2AGAA | |
| SCHEMBL1348420 | 0.68 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1KMT2ACYP19A1GAA | |
| SCHEMBL5508771 | 0.68 | MAPT (0.59) | TP53LMNANPSR1ALDH1A1MAPT | |
| SCHEMBL5502574 | 0.68 | MAPT (0.59) | TP53LMNANPSR1ALDH1A1MAPT | |
| SCHEMBL3412348 | 0.68 | CA1 (0.52) | ALDH1A1CYP19A1GAAMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |