Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 2/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27287741 | 1.00 | GRIA4 (0.56) | GRIA4GBA1LMNAMAPTTP53 | |
| SCHEMBL28762486 | 0.82 | GBA1 (0.55) | GRIA4GBA1LMNAMAPTTP53 | |
| SCHEMBL2934786 | 0.82 | ALDH1A1 (0.67) | GBA1ALDH1A1CYP19A1SIGMAR1MMP1 | |
| SCHEMBL9512047 | 0.79 | IDO1 (0.60) | ALDH1A1SMN1; SMN2MMP1MMP2MMP3 | |
| SCHEMBL3412348 | 0.79 | CA1 (0.52) | GBA1ALDH1A1CYP19A1SIGMAR1MMP1 | |
| SCHEMBL6321465 | 0.79 | CA1 (0.52) | GBA1ALDH1A1CYP19A1SIGMAR1MMP1 | |
| SCHEMBL6324078 | 0.79 | SIGMAR1 (0.51) | GBA1ALDH1A1CYP19A1SIGMAR1MMP1 | |
| SCHEMBL3412102 | 0.79 | CA1 (0.52) | GBA1ALDH1A1CYP19A1SIGMAR1MMP1 | |
| SCHEMBL5504602 | 0.79 | MMP1 (0.49) | GBA1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL9765326 | 0.78 | GRIA4 (0.63) | GRIA4GBA1LMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-B1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO MCNEIL PHARM INC (US) | 2005-02-16 | — | — | EP | disclosed |
| US-20040092505-A1 | Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone | COATS STEVEN J (US) | 2004-05-13 | — | — | US | disclosed |
| US-6583179-B2 | For therapy of uterine fibroids, endometriosis, polycystic ovarian disease, dysfunctional uterine bleeding, breast cancer and ovarian cancer; depletion of oocytes; spermatocyte depletion; for female and male contraception | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-06-24 | — | — | US | disclosed |
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-20020058654-A1 | Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-05-16 | — | — | US | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058654-A1 | Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone | FSHR, GNRHR, SHBG | GRIA4 488/4885GBA1 2608/4885LMNA 4290/4885 |
| US-20040092505-A1 | Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone | FSHR, GNRHR, SHBG | GRIA4 488/4885GBA1 2608/4885LMNA 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.