Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73992 | 0.91 | PDE4B (0.39) | PDE4BPDE5APDE4APDE4CPDE4D | |
| SCHEMBL75082 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HTTPDE4BPDE4APDE4C | |
| SCHEMBL85521 | 0.82 | PDE4D (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3873741 | 0.81 | PDE4B (0.36) | ALDH1A1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL73417 | 0.80 | PDE4D (0.38) | PDE4BPDE5APDE4APDE4CPDE4D | |
| SCHEMBL73450 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HTTPDE4BPDE4APDE4C | |
| SCHEMBL15041024 | 0.76 | BACE1 (0.32) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL73771 | 0.76 | PDE4D (0.40) | ALDH1A1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL73046 | 0.75 | PDE4D (0.44) | ALDH1A1PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL75050 | 0.69 | PDE4D (0.41) | ALDH1A1HTTPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831227-B1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-06-19 | — | — | EP | claimed |
| EP-1831227-B1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-06-19 | — | — | EP | disclosed |
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | disclosed |