Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3777509 | 0.87 | P2RX7 (0.52) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL3770109 | 0.83 | RXFP1 (0.55) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL713074 | 0.81 | P2RX7 (0.57) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL708523 | 0.79 | POLB (0.44) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL711146 | 0.79 | P2RX7 (0.53) | P2RX7 | |
| SCHEMBL5505044 | 0.79 | CXCR4 (0.43) | POLBP2RX7PDE1APDE1BPDE1C | |
| SCHEMBL3770854 | 0.79 | MC4R (0.61) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL710943 | 0.79 | P2RX7 (0.53) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL3777749 | 0.77 | MC4R (0.56) | POLBP2RX7RXFP1F2KMT2A | |
| SCHEMBL3771851 | 0.74 | MCHR1 (0.48) | POLBP2RX7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |