Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 9/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.68 |
| ▸ | CYP2E1 | P05181 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.68 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504375 | 0.83 | CYP2A6 (0.66) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL3604362 | 0.81 | CYP2A6 (1.00) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL15471025 | 0.80 | CYP2A6 (0.69) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL4869247 | 0.79 | CYP2A6 (0.59) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5209764 | 0.78 | CYP2A6 (0.67) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5504325 | 0.77 | CYP2A6 (0.66) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL8204568 | 0.77 | CYP2A6 (0.80) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5510809 | 0.77 | CYP2A6 (0.57) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL6690177 | 0.77 | CYP2A6 (0.74) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL13300562 | 0.77 | CYP2A6 (0.74) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749832-A2 | Carbamate and carbazate ketolide antibiotics | Pfizer Products Incorporated (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1298138-B1 | Carbamate and Carbazate Ketolide Antibiotics | PFIZER PROD INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-6664238-B1 | Such as 11-Deoxy-5-O-desosaminyl-11-(3,3-dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl -propyl))hydrazo-6-O-methyl-3-oxoerythronolide A,11,12-carbamate, 9-E-(O-methyl)oxime; antibacterial and antiprotozoal agents | PFIZER INC. | 2003-12-16 | — | — | US | disclosed |
| EP-1298138-A1 | Carbamate and Carbazate Ketolide Antibiotics | Pfizer Products Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1137654-A1 | CARBAMATE AND CARBAZATE KETOLIDE ANTIBIOTICS | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034297-A1 | CARBAMATE AND CARBAZATE KETOLIDE ANTIBIOTICS | PFIZER PRODUCTS INC. (US) | 2000-06-15 | — | — | WO | disclosed |