Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.43 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932196 | 0.87 | RARB (0.49) | LCKACMSDKLKB1CTSBMMP9 | |
| SCHEMBL1401542 | 0.85 | MRGPRX4 (0.51) | MRGPRX4LCKACMSDPARP1KLKB1 | |
| SCHEMBL5398835 | 0.84 | KAT8 (0.51) | MRGPRX4LCKPARP1KLKB1CTSB | |
| SCHEMBL109609 | 0.82 | LCK (0.52) | LCKACMSDKLKB1CTSBMMP9 | |
| SCHEMBL14670236 | 0.81 | MRGPRX4 (0.51) | MRGPRX4LCKPARP1KLKB1CTSB | |
| SCHEMBL6604457 | 0.79 | FOLH1 (0.57) | MRGPRX4LCKPARP1KLKB1CTSB | |
| SCHEMBL13622151 | 0.79 | MRGPRX4 (0.50) | MRGPRX4LCKPARP1KLKB1CTSB | |
| SCHEMBL18901395 | 0.79 | MRGPRX4 (0.50) | MRGPRX4LCKPARP1KLKB1CTSB | |
| SCHEMBL11888130 | 0.79 | METAP2 (0.51) | MRGPRX4PARP1KLKB1CTSBMMP9 | |
| SCHEMBL30851337 | 0.79 | MRGPRX4 (0.50) | MRGPRX4LCKPARP1KLKB1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100393698-C | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparation and pharmaceutical compositions containing them | JE IL PHARMACEUTICAL CO LTD (KR) | 2008-06-11 | — | — | CN | disclosed |
| CN-101124201-A | PARP inhibitors | KUDOS PHARM LTD (GB) | 2008-02-13 | — | — | CN | disclosed |
| EP-1828118-A1 | PARP INHIBITORS | Kudos Pharmaceuticals Ltd (GB) | 2007-09-05 | — | — | EP | disclosed |
| CN-1826316-A | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparation and pharmaceutical compositions containing them | JE IL PHARMACEUTICAL CO LTD (KR) | 2006-08-30 | — | — | CN | disclosed |
| WO-2006067472-A1 | PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135770-A1 | PARP inhibitors | KUDOS PHARMACEUTICALS LTD. (GB) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135770-A1 | PARP inhibitors | PARP2, PARP1, PARP3 | MRGPRX4 2313/4885LCK 4466/4885ACMSD 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.