⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550638 | 1.00 | — | — | |
| SCHEMBL3863769 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL15422026 | 0.96 | — | — | |
| Hydrochloric Acid SCHEMBL629821 | 0.96 | — | — | |
| Hydrochloric Acid SCHEMBL629822 | 0.96 | — | — | |
| SCHEMBL14615682 | 0.81 | — | — | |
| SCHEMBL6904890 | 0.77 | TSHR (0.50) | — | |
| SCHEMBL15702330 | 0.77 | TSHR (0.50) | — | |
| SCHEMBL4100101 | 0.72 | ANPEP (0.47) | — | |
| SCHEMBL13448317 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | claimed |
| EP-2102194-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | claimed |
| WO-2008068171-A9 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-07-16 | — | — | WO | claimed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | claimed |
| CN-119161334-A | Amide derivative containing thiophene structure, preparation method and application thereof | 贵州大学 | 2024-12-20 | — | — | CN | disclosed |
| US-11459312-B2 | Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-04 | — | — | US | disclosed |
| CN-113248497-B | Fused ring derivatives useful as FGFR4 inhibitors | 北京加科思新药研发有限公司 | 2022-08-19 | — | — | CN | disclosed |
| US-20220119386-A1 | FUSED RING DERIVATIVE USED AS FGFR4 INHIBITOR | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2022-04-21 | — | — | US | disclosed |
| US-11299457-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2022-04-12 | — | — | US | disclosed |
| US-11136320-B2 | Fused ring derivative used as FGFR4 inhibitor | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-10-05 | — | — | US | disclosed |
| CN-113248497-A | Fused ring derivatives useful as FGFR4 inhibitors | 北京加科思新药研发有限公司 | 2021-08-13 | — | — | CN | disclosed |
| WO-2003099777-A1 | PROCESS FOR THE PREPARATION OF THIOALKYLAMINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2003-12-04 | — | — | WO | disclosed |
| US-6639109-B1 | Reacting amino alcohol with sulfuric acid then reacting resulting amino sulfate with a mercaptan; simple, safe, rapid | NIHON NOHYAKU CO., LTD. (JP) | 2003-10-28 | — | — | US | disclosed |
| US-6603044-B1 | The present invention provides a phthalamide derivative of the formula (I): agrohorticultural insecticide containing said compound as active ingredient and exhibiting an excellent insecticidal effect. | NIHON NOHYAKU CO., LTD. (JP) | 2003-08-05 | — | — | US | disclosed |
| EP-1216988-A1 | THIOALKYLAMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Nihon Nohyaku Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |
| EP-1006107-A2 | Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same | NIHON NOHYAKU CO., LTD. (JP) | 2000-06-07 | — | — | EP | disclosed |
| US-4650905-A | PRE- AND POSTEMERGENCE HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1987-03-17 | — | — | US | disclosed |
| EP-0116167-B1 | DIPHENYLETHERS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN COMBATTING WEEDS | BASF Aktiengesellschaft (DE) | 1986-02-26 | — | — | EP | disclosed |
| EP-0116167-A1 | Diphenylethers, process for their preparation and their use in combatting weeds | BASF Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | disclosed |